Entropic effects in channel-facilitated transport: interparticle interactions break the flux symmetry.
نویسندگان
چکیده
We analyze transport through conical channels that is driven by the difference in particle concentrations on the two sides of the membrane. Because of the detailed balance, fluxes of noninteracting particles through the same channel, inserted into the membrane in two opposite orientations, are equal. We show that this flux symmetry is broken by particle-particle interactions so that one of the orientations can be much more efficient for transport under the same external conditions. The results are obtained analytically using a one-dimensional diffusion model and confirmed by three-dimensional Brownian dynamics simulations.
منابع مشابه
Rectification Through Entropic Barriers
The dynamics of Brownian motion has widespread applications extending from transport in designed micro-channels up to its prominent role for inducing transport in molecular motors and Brownian motors. Here, Brownian transport is studied in micro-sized, two dimensional periodic channels, exhibiting periodically varying cross sections. The particles in addition are subjected to a constant externa...
متن کاملInteractions between Membrane Inclusions on Fluctuating Membranes
We model membrane proteins as anisotropic objects characterized by symmetric-traceless tensors and determine the coupling between these orderparameters and membrane curvature. We consider the interactions 1) between transmembrane proteins that respect up-down (reflection) symmetry of bilayer membranes and that have circular or non-circular cross-sectional areas in the tangent-plane of membranes...
متن کاملEffects of multiple occupancy and interparticle interactions on selective transport through narrow channels: theory versus experiment.
Many biological and artificial transport channels function without direct input of metabolic energy during a transport event and without structural rearrangements involving transitions from a closed to an open state. Nevertheless, such channels are able to maintain efficient and selective transport. It has been proposed that attractive interactions between the transported molecules and the chan...
متن کاملChannel-facilitated molecular transport: The role of strength and spatial distribution of interactions
Molecular transport across channels and pores is critically important for multiple natural and industrial processes. Recent advances in single-molecule techniques have allowed researchers to probe translocation through nanopores with unprecedented spatial and temporal resolution. However, our understanding of the mechanisms of channel-facilitated molecular transport is still not complete. We pr...
متن کاملEffect of the Interparticle Interactions on Adsorption-Induced Frequency Shift of Nano-beam-Based Nanoscale Mass-Sensors: A Theoretical Study
It is well-known that the Interparticle interactions between adsorbates and surface of an adsorbent can affect the surface morphology. One of the consequences of this issue is that the resonant frequency of a nanoscale resonator can be changed due to adsorption. In this study we have chosen a cantilever-based nanoscale mass-sensor with a single nanoparticle at its tip. Using the classical...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Physical review. E, Statistical, nonlinear, and soft matter physics
دوره 80 2 Pt 1 شماره
صفحات -
تاریخ انتشار 2009